EDUCATION
All About Progesterone
Progesterone is a steroid hormone, classified within the progestogen family, synthesised from cholesterol. Its production is primarily regulated by luteinising hormone (LH), which surges at mid-cycle, prompting ovulation. Progesterone serves as a critical signalling molecule in reproductive physiology, preparing the endometrium for implantation and sustaining pregnancy should fertilisation occur.
Article Series
What is progesterone?
Progesterone is a steroid hormone, classified within the progestogen family, synthesised from cholesterol. Its production is primarily regulated by luteinising hormone (LH), which surges at mid-cycle, prompting ovulation. Progesterone serves as a critical signalling molecule in reproductive physiology, preparing the endometrium for implantation and sustaining pregnancy should fertilisation occur.
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The Role of Progesterone in Fertility Treatments
Progesterone is a pivotal steroid hormone in reproductive physiology, exerting multifaceted effects on endometrial receptivity, implantation, and immune tolerance. Its indispensable role in establishing and maintaining pregnancy underscores its widespread use in fertility treatments, particularly in assisted reproductive technologies (ART) and ovulation induction protocols.
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Progesterone Hypersensitivity and Intolerance in Fertility Treatment
Progesterone plays an indispensable role in reproductive endocrinology, particularly in the context of fertility treatments where exogenous supplementation is frequently employed to support implantation and early pregnancy. However, a subset of individuals exhibit hypersensitivity or intolerance to progesterone, manifesting as immune-mediated reactions or physiological intolerance to endogenous or exogenous progesterone.
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